EGF
Summary: This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| epidermal growth factor | MIM:131530 | Ensembl:ENSG00000138798 | HGNC:HGNC:3229 | PA27664 | 4q25 |
GO terms in EGF
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005154 | epidermal growth factor receptor binding |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008083 | growth factor activity |
| MF | IBA | GO:0017147 | Wnt-protein binding |
| MF | TAS | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity |
| MF | IBA | GO:0042813 | Wnt-activated receptor activity |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| CC | TAS | GO:0005576 | extracellular region |
| CC | HDA | GO:0005615 | extracellular space |
| CC | HDA | GO:0005765 | lysosomal membrane |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | TAS | GO:0030665 | clathrin-coated vesicle membrane |
| CC | TAS | GO:0031093 | platelet alpha granule lumen |
| CC | IBA | GO:0043235 | receptor complex |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000186 | activation of MAPKK activity |
| BP | IEA | GO:0000187 | activation of MAPK activity |
| BP | IDA | GO:0001525 | angiogenesis |
| BP | IDA | GO:0002092 | positive regulation of receptor internalization |
| BP | TAS | GO:0002576 | platelet degranulation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007171 | activation of transmembrane receptor protein tyrosine kinase activity |
| BP | TAS | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IDA | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0021940 | positive regulation of cerebellar granule cell precursor proliferation |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | TAS | GO:0038128 | ERBB2 signaling pathway |
| BP | TAS | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| BP | IDA | GO:0042327 | positive regulation of phosphorylation |
| BP | ISS | GO:0043388 | positive regulation of DNA binding |
| BP | IDA | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IBA | GO:0044332 | Wnt signaling pathway involved in dorsal/ventral axis specification |
| BP | IDA | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity |
| BP | IMP | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity |
| BP | TAS | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity |
| BP | TAS | GO:0045746 | negative regulation of Notch signaling pathway |
| BP | IDA | GO:0045840 | positive regulation of mitotic nuclear division |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | ISS | GO:0046425 | regulation of JAK-STAT cascade |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IEA | GO:0048754 | branching morphogenesis of an epithelial tube |
| BP | IDA | GO:0051048 | negative regulation of secretion |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IBA | GO:0060070 | canonical Wnt signaling pathway |
| BP | IEA | GO:0060749 | mammary gland alveolus development |
| BP | TAS | GO:0061024 | membrane organization |
| BP | IDA | GO:0070371 | ERK1 and ERK2 cascade |
| BP | IDA | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IDA | GO:0090279 | regulation of calcium ion import |
| BP | IEA | GO:0090370 | negative regulation of cholesterol efflux |
| BP | IDA | GO:1900127 | positive regulation of hyaluronan biosynthetic process |
| BP | TAS | GO:1901185 | negative regulation of ERBB signaling pathway |
| BP | IDA | GO:2000008 | regulation of protein localization to cell surface |
| BP | IEA | GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process |
| BP | TAS | GO:2000145 | regulation of cell motility |
Gene expression in normal tissue: EGF
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EGF
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1251932 | PLCG1 events in ERBB2 signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643713 | Signaling by EGFR in Cancer |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-179812 | GRB2 events in EGFR signaling |
| reactome | R-HSA-180292 | GAB1 signalosome |
| reactome | R-HSA-180336 | SHC1 events in EGFR signaling |
| reactome | R-HSA-182971 | EGFR downregulation |
| reactome | R-HSA-1963640 | GRB2 events in ERBB2 signaling |
| reactome | R-HSA-1963642 | PI3K events in ERBB2 signaling |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-212718 | EGFR interacts with phospholipase C-gamma |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-5637810 | Constitutive Signaling by EGFRvIII |
| reactome | R-HSA-5637812 | Signaling by EGFRvIII in Cancer |
| reactome | R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| reactome | R-HSA-5638302 | Signaling by Overexpressed Wild-Type EGFR in Cancer |
| reactome | R-HSA-5638303 | Inhibition of Signaling by Overexpressed EGFR |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6785631 | ERBB2 Regulates Cell Motility |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| reactome | R-HSA-8847993 | ERBB2 Activates PTK6 Signaling |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| reactome | R-HSA-8863795 | Downregulation of ERBB2 signaling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9013507 | NOTCH3 Activation and Transmission of Signal to the Nucleus |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| biocarta | cblpathway | cbl mediated ligand-induced downregulation of egf receptors pathway |
| biocarta | egfpathway | egf signaling pathway |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | mcalpainpathway | mcalpain and friends in cell motility |
| biocarta | smrtepathway | map kinase inactivation of smrt corepressor |
| biocarta | sprypathway | sprouty regulation of tyrosine kinase signals |
| pid | a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | arf6_pathway | Arf6 signaling events |
| pid | ceramide_pathway | Ceramide signaling pathway |
| pid | ecadherin_stabilization_pathway | Stabilization and expansion of the E-cadherin adherens junction |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | erbb1_internalization_pathway | Internalization of ErbB1 |
| pid | erbb_network_pathway | ErbB receptor signaling network |
| pid | et_egfrpathway | EGFR-dependent Endothelin signaling events |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | shp2_pathway | SHP2 signaling |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| pid | telomerasepathway | Regulation of Telomerase |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05219 | Bladder cancer - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP2571 | Polycystic Kidney Disease Pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP2804 | Hair Follicle Development- Induction (Part 1 of 3) |
| wikipathways | WP2828 | Bladder Cancer |
| wikipathways | WP2848 | Differentiation Pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3624 | Lung fibrosis |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3853 | ERK Pathway in Huntington,s Disease |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| wikipathways | WP673 | ErbB Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD394 | BX-795 | 4 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD71 | Sparfosic acid | 2 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD792 | Cetuximab | 1 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD158 | NSC141540 | 5 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD886 | Compound 1541A | 9 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD147 | Prima-1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EGF
CLASSFICATION
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