ARID2

Summary: This gene encodes a member of the AT-rich interactive domain (ARID)-containing family of DNA-binding proteins. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and chromatin structure modification. This protein functions as a subunit of the polybromo- and BRG1-associated factor or PBAF (SWI/SNF-B) chromatin remodeling complex which facilitates ligand-dependent transcriptional activation by nuclear receptors. Mutations in this gene are associated with hepatocellular carcinomas. A pseudogene of this gene is found on chromosome1. [provided by RefSeq, Dec 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameAT-rich interaction domain 2
OMIM IDMIM:609539
Ensembl IDEnsembl:ENSG00000189079
HGNC IDHGNC:HGNC:18037
PHARMGKB IDPA134916396
Map Location12q12

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in ARID2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IEA GO:0003677 DNA binding
MF IPI GO:0005515 protein binding
MF IEA GO:0046872 metal ion binding
BP IEA GO:0003007 heart morphogenesis
BP IDA GO:0006337 nucleosome disassembly
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Gene expression in normal tissue: ARID2

Gene-model tissue-cancer distribution: Bubble Plot

SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Cutaneous Melanoma (SKCM) model num: 9BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: Colorectal Adenocarcinoma (COADREAD) model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1STOMACtissue: STOMAC cancer: STOMACH model num: 0STOMACHtissue: STOMACH cancer: Esophageal Adenocarcinoma (ESCA) model num: 1STOMACHtissue: STOMACH cancer: Stomach Adenocarcinoma (STAD) model num: 1OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: Ovarian Cancer model num: 1

Gene-drug pathway distribution

Pathways in ARID2


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Database
Pathway ID
Pathway Des.
wikipathways WP2004 miR-targeted genes in lymphocytes - TarBase
kegg hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
reactome R-HSA-212436 Generic Transcription Pathway
reactome R-HSA-3214858 RMTs methylate histone arginines
reactome R-HSA-3247509 Chromatin modifying enzymes
reactome R-HSA-4839726 Chromatin organization
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD462 OSI-906 (Linsitinib) 1
iGMDRD309 17AAG 1
iGMDRD232 FTI-277 1
iGMDRD678 Tubastatin A 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARID2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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