ARID2
Summary: This gene encodes a member of the AT-rich interactive domain (ARID)-containing family of DNA-binding proteins. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and chromatin structure modification. This protein functions as a subunit of the polybromo- and BRG1-associated factor or PBAF (SWI/SNF-B) chromatin remodeling complex which facilitates ligand-dependent transcriptional activation by nuclear receptors. Mutations in this gene are associated with hepatocellular carcinomas. A pseudogene of this gene is found on chromosome1. [provided by RefSeq, Dec 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| AT-rich interaction domain 2 | MIM:609539 | Ensembl:ENSG00000189079 | HGNC:HGNC:18037 | PA134916396 | 12q12 |
Gene Categories:
CLINICALLY ACTIONABLEGO terms in ARID2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0003007 | heart morphogenesis |
| BP | IDA | GO:0006337 | nucleosome disassembly |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0030336 | negative regulation of cell migration |
| BP | IEA | GO:0042592 | homeostatic process |
| BP | IEA | GO:0048568 | embryonic organ development |
| BP | IEA | GO:0060038 | cardiac muscle cell proliferation |
| BP | IEA | GO:0060982 | coronary artery morphogenesis |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
Gene expression in normal tissue: ARID2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARID2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3214858 | RMTs methylate histone arginines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD232 | FTI-277 | 1 |
| iGMDRD678 | Tubastatin A | 1 |
| iGMDRD125 | BIRB-796 | 1 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD507 | GSK690693 | 1 |
| iGMDRD392 | Masitinib | 1 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD776 | QL-XI-92 | 1 |
| iGMDRD384 | EHT-1864 | 1 |
| iGMDRD472 | PF-562271 | 1 |
| iGMDRD178 | MG-132 | 1 |
| iGMDRD608 | Refametinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARID2
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