NLRC3
Summary: This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:615648 Ensembl IDEnsembl:ENSG00000167984 HGNC IDHGNC:HGNC:29889 PHARMGKB IDPA162397626 Map Location16p13.3 | |||||
GO terms in NLRC3
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | ISS | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: NLRC3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NLRC3
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-1834941 | STING mediated induction of host immune responses |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-3270619 | IRF3-mediated induction of type I IFN |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NLRC3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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