NLRC3
Summary: This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NLR family CARD domain containing 3 | MIM:615648 | Ensembl:ENSG00000167984 | HGNC:HGNC:29889 | PA162397626 | 16p13.3 |
GO terms in NLRC3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | ISS | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005815 | microtubule organizing center |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| BP | IDA | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | ISS | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling |
| BP | IBA | GO:0023052 | signaling |
| BP | IDA | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | ISS | GO:0032687 | negative regulation of interferon-alpha production |
| BP | ISS | GO:0032688 | negative regulation of interferon-beta production |
| BP | IDA | GO:0032715 | negative regulation of interleukin-6 production |
| BP | IMP | GO:0032715 | negative regulation of interleukin-6 production |
| BP | IDA | GO:0032720 | negative regulation of tumor necrosis factor production |
| BP | IMP | GO:0032720 | negative regulation of tumor necrosis factor production |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IEP | GO:0042110 | T cell activation |
| BP | IBA | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IMP | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | ISS | GO:0045824 | negative regulation of innate immune response |
| BP | ISS | GO:0048147 | negative regulation of fibroblast proliferation |
| BP | ISS | GO:0050680 | negative regulation of epithelial cell proliferation |
| BP | IDA | GO:0050728 | negative regulation of inflammatory response |
| BP | ISS | GO:1900016 | negative regulation of cytokine production involved in inflammatory response |
| BP | IDA | GO:1900226 | negative regulation of NLRP3 inflammasome complex assembly |
| BP | IDA | GO:1901223 | negative regulation of NIK/NF-kappaB signaling |
Gene expression in normal tissue: NLRC3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NLRC3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-1834941 | STING mediated induction of host immune responses |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-3270619 | IRF3-mediated induction of type I IFN |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NLRC3
CLASSFICATION
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