NLRC3


Summary: This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
NLR family CARD domain containing 3MIM:615648Ensembl:ENSG00000167984HGNC:HGNC:29889PA16239762616p13.3

GO terms in NLRC3


Term TypeEvidence TypeGO Term IDGO Des.
MFNDGO:0003674molecular_function
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFISSGO:0036312phosphatidylinositol 3-kinase regulatory subunit binding
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005815microtubule organizing center
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCIDAGO:0048471perinuclear region of cytoplasm
BPIDAGO:0007249I-kappaB kinase/NF-kappaB signaling
BPISSGO:0014067negative regulation of phosphatidylinositol 3-kinase signaling
BPIBAGO:0023052signaling
BPIDAGO:0032088negative regulation of NF-kappaB transcription factor activity
BPISSGO:0032687negative regulation of interferon-alpha production
BPISSGO:0032688negative regulation of interferon-beta production
BPIDAGO:0032715negative regulation of interleukin-6 production
BPIMPGO:0032715negative regulation of interleukin-6 production
BPIDAGO:0032720negative regulation of tumor necrosis factor production
BPIMPGO:0032720negative regulation of tumor necrosis factor production
BPIBAGO:0035556intracellular signal transduction
BPIEPGO:0042110T cell activation
BPIBAGO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling
BPIMPGO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling
BPISSGO:0045824negative regulation of innate immune response
BPISSGO:0048147negative regulation of fibroblast proliferation
BPISSGO:0050680negative regulation of epithelial cell proliferation
BPIDAGO:0050728negative regulation of inflammatory response
BPISSGO:1900016negative regulation of cytokine production involved in inflammatory response
BPIDAGO:1900226negative regulation of NLRP3 inflammasome complex assembly
BPIDAGO:1901223negative regulation of NIK/NF-kappaB signaling

Gene expression in normal tissue: NLRC3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NLRC3


DatabasePathway IDPathway Des.
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-1834941STING mediated induction of host immune responses
reactomeR-HSA-1834949Cytosolic sensors of pathogen-associated DNA
reactomeR-HSA-3270619IRF3-mediated induction of type I IFN

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NLRC3

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