AIF1
Summary: This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes. Polymorphisms in this gene may be associated with systemic sclerosis. Alternative splicing results in multiple transcript variants, but the full-length and coding nature of some of these variants is not certain. [provided by RefSeq, Jan 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601833 Ensembl IDEnsembl:ENSG00000204472 HGNC IDHGNC:HGNC:352 PHARMGKB IDPA24646 Map Location6p21.33 | |||||
Gene Categories:
TUMOR SUPPRESSORGO terms in AIF1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IBA | GO:0005509 | calcium ion binding |
| MF | ISS | GO:0005509 | calcium ion binding |
| MF | IBA | GO:0051015 | actin filament binding |
| MF | IDA | GO:0051015 | actin filament binding |
| CC | ISS | GO:0001891 | phagocytic cup |
Gene expression in normal tissue: AIF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AIF1
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AIF1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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