EPHB4
Summary: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| EPH receptor B4 | MIM:600011 | Ensembl:ENSG00000196411 | HGNC:HGNC:3395 | PA27827 | 7q22.1 |
GO terms in EPHB4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IDA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IDA | GO:0005003 | ephrin receptor activity |
| MF | IBA | GO:0005005 | transmembrane-ephrin receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| BP | ISS | GO:0001525 | angiogenesis |
| BP | IDA | GO:0002042 | cell migration involved in sprouting angiogenesis |
| BP | ISS | GO:0003007 | heart morphogenesis |
| BP | IDA | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0048013 | ephrin receptor signaling pathway |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0043005 | neuron projection |
| CC | IBA | GO:0043235 | receptor complex |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: EPHB4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPHB4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928664 | Ephrin signaling |
| reactome | R-HSA-3928664 | Ephrin signaling |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| pid | ephbfwdpathway | EPHB forward signaling |
| pid | ephrinbrevpathway | Ephrin B reverse signaling |
| netpath | Pathway_EGFR1 | EGFR1 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 7 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD837 | Bevacizumab | 1 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD23 | Gossypol | 5 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD131 | Erlotinib | 1 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD409 | Saracatinib | 2 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD427 | ABT737 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPHB4
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