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SENP5

Summary: The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
SUMO specific peptidase 5	MIM:612845	Ensembl:ENSG00000119231	HGNC:HGNC:28407	PA134917083	3q29

Gene Categories:

PROTEASE DRUGGABLE GENOME

GO terms in SENP5

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0007049	cell cycle
BP	TAS	GO:0016925	protein sumoylation
BP	IBA	GO:0016926	protein desumoylation
BP	IEA	GO:0051301	cell division
CC	IBA	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	IEA	GO:0005730	nucleolus
MF	IPI	GO:0005515	protein binding
MF	EXP	GO:0070139	SUMO-specific endopeptidase activity

Gene expression in normal tissue: SENP5

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SENP5

Database	Pathway ID	Pathway Des.
reactome	R-HSA-2990846	SUMOylation
reactome	R-HSA-3065679	SUMO is proteolytically processed
reactome	R-HSA-3215018	Processing and activation of SUMO
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-597592	Post-translational protein modification

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SENP5

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CLASSFICATION

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