EPRS
Summary: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glutamyl-prolyl-tRNA synthetase | MIM:138295 | Ensembl:ENSG00000136628 | HGNC:HGNC:3418 | PA27837 | 1q41 |
Gene Categories:
DRUGGABLE GENOMEGO terms in EPRS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004818 | glutamate-tRNA ligase activity |
| MF | IBA | GO:0004827 | proline-tRNA ligase activity |
| MF | IDA | GO:0004827 | proline-tRNA ligase activity |
| MF | TAS | GO:0004827 | proline-tRNA ligase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IDA | GO:0035613 | RNA stem-loop binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0051020 | GTPase binding |
| BP | TAS | GO:0006418 | tRNA aminoacylation for protein translation |
| BP | IBA | GO:0006433 | prolyl-tRNA aminoacylation |
| BP | IDA | GO:0006433 | prolyl-tRNA aminoacylation |
| BP | IDA | GO:0017148 | negative regulation of translation |
| BP | IMP | GO:0017148 | negative regulation of translation |
| BP | ISS | GO:0032869 | cellular response to insulin stimulus |
| BP | IMP | GO:0044539 | long-chain fatty acid import |
| BP | TAS | GO:0065003 | protein-containing complex assembly |
| BP | IDA | GO:0071346 | cellular response to interferon-gamma |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex |
| CC | IDA | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex |
| CC | IDA | GO:0097452 | GAIT complex |
| CC | IDA | GO:1990904 | ribonucleoprotein complex |
Gene expression in normal tissue: EPRS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPRS
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00860 | Porphyrin and chlorophyll metabolism - Homo sapiens (human) |
| kegg | hsa00970 | Aminoacyl-tRNA biosynthesis - Homo sapiens (human) |
| netpath | Pathway_TCR | TCR |
| humancyc | TRNA-CHARGING-PWY | tRNA charging |
| wikipathways | WP2371 | Parkinsons Disease Pathway |
| wikipathways | WP3925 | Amino Acid metabolism |
| smpdb | SMP00020 | Arginine and Proline Metabolism |
| smpdb | SMP00188 | Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) |
| smpdb | SMP00207 | Prolidase Deficiency (PD) |
| smpdb | SMP00208 | Prolinemia Type II |
| smpdb | SMP00360 | Hyperprolinemia Type II |
| smpdb | SMP00361 | Hyperprolinemia Type I |
| smpdb | SMP00362 | Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) |
| smpdb | SMP00363 | Ornithine Aminotransferase Deficiency (OAT Deficiency) |
| smpdb | SMP00504 | Creatine deficiency, guanidinoacetate methyltransferase deficiency |
| smpdb | SMP00505 | Hyperornithinemia with gyrate atrophy (HOGA) |
| smpdb | SMP00506 | Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome] |
| smpdb | SMP00507 | L-arginine:glycine amidinotransferase deficiency |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-2408517 | SeMet incorporation into proteins |
| reactome | R-HSA-2408522 | Selenoamino acid metabolism |
| reactome | R-HSA-379716 | Cytosolic tRNA aminoacylation |
| reactome | R-HSA-379724 | tRNA Aminoacylation |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-6782315 | tRNA modification in the nucleus and cytosol |
| reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
| reactome | R-HSA-72306 | tRNA processing |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPRS
CLASSFICATION
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