EPRS
Summary: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:138295 Ensembl IDEnsembl:ENSG00000136628 HGNC IDHGNC:HGNC:3418 PHARMGKB IDPA27837 Map Location1q41 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in EPRS
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004818 | glutamate-tRNA ligase activity |
| MF | IBA | GO:0004827 | proline-tRNA ligase activity |
| MF | IDA | GO:0004827 | proline-tRNA ligase activity |
| MF | TAS | GO:0004827 | proline-tRNA ligase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: EPRS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPRS
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00860 | Porphyrin and chlorophyll metabolism - Homo sapiens (human) |
| kegg | hsa00970 | Aminoacyl-tRNA biosynthesis - Homo sapiens (human) |
| netpath | Pathway_TCR | TCR |
| humancyc | TRNA-CHARGING-PWY | tRNA charging |
| wikipathways | WP2371 | Parkinsons Disease Pathway |
| wikipathways | WP3925 | Amino Acid metabolism |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPRS
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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