EREG
Summary: This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| epiregulin | MIM:602061 | Ensembl:ENSG00000124882 | HGNC:HGNC:3443 | PA27856 | 4q13.3 |
GO terms in EREG
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | ISS | GO:0001550 | ovarian cumulus expansion |
| BP | ISS | GO:0001556 | oocyte maturation |
| BP | ISS | GO:0001819 | positive regulation of cytokine production |
| BP | ISS | GO:0007143 | female meiotic nuclear division |
| BP | IBA | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | ISS | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | IDA | GO:0007267 | cell-cell signaling |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | ISS | GO:0008284 | positive regulation of cell proliferation |
| BP | ISS | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0009299 | mRNA transcription |
| BP | TAS | GO:0009653 | anatomical structure morphogenesis |
| BP | TAS | GO:0009887 | animal organ morphogenesis |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IDA | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0030216 | keratinocyte differentiation |
| BP | ISS | GO:0030728 | ovulation |
| BP | TAS | GO:0038128 | ERBB2 signaling pathway |
| BP | TAS | GO:0042060 | wound healing |
| BP | IDA | GO:0042108 | positive regulation of cytokine biosynthetic process |
| BP | IDA | GO:0042327 | positive regulation of phosphorylation |
| BP | ISS | GO:0042327 | positive regulation of phosphorylation |
| BP | ISS | GO:0042700 | luteinizing hormone signaling pathway |
| BP | IEA | GO:0043434 | response to peptide hormone |
| BP | IDA | GO:0043616 | keratinocyte proliferation |
| BP | ISS | GO:0045089 | positive regulation of innate immune response |
| BP | ISS | GO:0045410 | positive regulation of interleukin-6 biosynthetic process |
| BP | IDA | GO:0045740 | positive regulation of DNA replication |
| BP | ISS | GO:0045740 | positive regulation of DNA replication |
| BP | ISS | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity |
| BP | ISS | GO:0045840 | positive regulation of mitotic nuclear division |
| BP | IDA | GO:0045860 | positive regulation of protein kinase activity |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IDA | GO:0048146 | positive regulation of fibroblast proliferation |
| BP | ISS | GO:0048160 | primary follicle stage |
| BP | ISS | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | TAS | GO:0050680 | negative regulation of epithelial cell proliferation |
| BP | IDA | GO:0051151 | negative regulation of smooth muscle cell differentiation |
| BP | IEA | GO:0051781 | positive regulation of cell division |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | TAS | GO:2000145 | regulation of cell motility |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005622 | intracellular |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IBA | GO:0005154 | epidermal growth factor receptor binding |
| MF | ISS | GO:0005154 | epidermal growth factor receptor binding |
| MF | TAS | GO:0005154 | epidermal growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008083 | growth factor activity |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
Gene expression in normal tissue: EREG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EREG
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1250342 | PI3K events in ERBB4 signaling |
| reactome | R-HSA-1250347 | SHC1 events in ERBB4 signaling |
| reactome | R-HSA-1251985 | Nuclear signaling by ERBB4 |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1963640 | GRB2 events in ERBB2 signaling |
| reactome | R-HSA-1963642 | PI3K events in ERBB2 signaling |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6785631 | ERBB2 Regulates Cell Motility |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-8847993 | ERBB2 Activates PTK6 Signaling |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8863795 | Downregulation of ERBB2 signaling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| pid | erbb_network_pathway | ErbB receptor signaling network |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| wikipathways | WP673 | ErbB Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD898 | EGFR mAb inhibitor | 2 |
| iGMDRD792 | Cetuximab | 1 |
| iGMDRD967 | Panitumumab | 1 |
| iGMDRD816 | anti-EGFR mAbs | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EREG
CLASSFICATION
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