EREG
Summary: This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameepiregulin OMIM IDMIM:602061 Ensembl IDEnsembl:ENSG00000124882 HGNC IDHGNC:HGNC:3443 PHARMGKB IDPA27856 Map Location4q13.3 | |||||
GO terms in EREG
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | ISS | GO:0001550 | ovarian cumulus expansion |
| BP | ISS | GO:0001556 | oocyte maturation |
| BP | ISS | GO:0001819 | positive regulation of cytokine production |
| BP | ISS | GO:0007143 | female meiotic nuclear division |
Gene expression in normal tissue: EREG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EREG
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EREG
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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