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ERCC4

Summary: The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameERCC excision repair 4, endonuclease catalytic subunit OMIM IDMIM:133520 Ensembl IDEnsembl:ENSG00000175595 HGNC IDHGNC:HGNC:3436 PHARMGKB IDPA27850 Map Location16p13.12

Gene Categories:

CLINICALLY ACTIONABLE TRANSCRIPTION FACTOR BINDING DNA REPAIR TRANSCRIPTION FACTOR COMPLEX

GO terms in ERCC4

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0000014	single-stranded DNA endodeoxyribonuclease activity
MF	IEA	GO:0001094	TFIID-class transcription factor binding
MF	IDA	GO:0003677	DNA binding
MF	IBA	GO:0003684	damaged DNA binding
MF	IMP	GO:0003684	damaged DNA binding
MF	IBA	GO:0003697	single-stranded DNA binding

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Gene expression in normal tissue: ERCC4

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ERCC4

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-5685938	HDR through Single Strand Annealing (SSA)
reactome	R-HSA-5693532	DNA Double-Strand Break Repair
reactome	R-HSA-5693538	Homology Directed Repair
reactome	R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactome	R-HSA-5696395	Formation of Incision Complex in GG-NER
reactome	R-HSA-5696398	Nucleotide Excision Repair

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD61	Kinetin riboside	6
iGMDRD211	(1S,3R)-RSL3	3
iGMDRD605	AZD6482	1
iGMDRD126	Tipifarnib	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ERCC4

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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