ETS2

Summary: This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameETS proto-oncogene 2, transcription factor
OMIM IDMIM:164740
Ensembl IDEnsembl:ENSG00000157557
HGNC IDHGNC:HGNC:3489
PHARMGKB IDPA27903
Map Location21q22.2

GO terms in ETS2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF IBA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IDA GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
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Gene expression in normal tissue: ETS2

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Non-Small Cell Lung Cancer (NSCLC) model num: 2

Gene-drug pathway distribution

Pathways in ETS2


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Database
Pathway ID
Pathway Des.
kegg hsa04014 Ras signaling pathway - Homo sapiens (human)
kegg hsa05166 HTLV-I infection - Homo sapiens (human)
pid cmyb_pathway C-MYB transcription factor network
netpath Pathway_IL2 IL2
wikipathways WP289 Myometrial Relaxation and Contraction Pathways
wikipathways WP3308 Oncogene Induced Senescence
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD160 Cis-Platin 1
iGMDRD68 Paclitaxel 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ETS2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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