ALDH3A1
Summary: Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:100660 Ensembl IDEnsembl:ENSG00000108602 HGNC IDHGNC:HGNC:405 PHARMGKB IDPA24697 Map Location17p11.2 | |||||
GO terms in ALDH3A1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity |
| MF | IEA | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity |
| MF | IDA | GO:0004029 | aldehyde dehydrogenase (NAD) activity |
| MF | TAS | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008106 | alcohol dehydrogenase (NADP+) activity |
Gene expression in normal tissue: ALDH3A1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ALDH3A1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-211859 | Biological oxidations |
| reactome | R-HSA-211945 | Phase I - Functionalization of compounds |
| smpdb | SMP00006 | Tyrosine Metabolism |
| smpdb | SMP00039 | Glycerolipid Metabolism |
| smpdb | SMP00044 | Histidine Metabolism |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ALDH3A1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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