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FAH

Summary: This gene encodes the last enzyme in the tyrosine catabolism pathway. FAH deficiency is associated with Type 1 hereditary tyrosinemia (HT). [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namefumarylacetoacetate hydrolase OMIM IDMIM:613871 Ensembl IDEnsembl:ENSG00000103876 HGNC IDHGNC:HGNC:3579 PHARMGKB IDPA27977 Map Location15q25.1

GO terms in FAH

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	TAS	GO:0005829	cytosol
CC	HDA	GO:0070062	extracellular exosome
BP	IEA	GO:0006527	arginine catabolic process
BP	IEA	GO:0006559	L-phenylalanine catabolic process
BP	TAS	GO:0006559	L-phenylalanine catabolic process
BP	IEA	GO:0006572	tyrosine catabolic process

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Gene expression in normal tissue: FAH

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FAH

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-6788656	Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism
reactome	R-HSA-71182	Phenylalanine and tyrosine catabolism
reactome	R-HSA-71291	Metabolism of amino acids and derivatives
kegg	hsa00350	Tyrosine metabolism - Homo sapiens (human)
humancyc	TYRFUMCAT-PWY	tyrosine degradation

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FAH

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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