FAT2
Summary: This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| FAT atypical cadherin 2 | MIM:604269 | Ensembl:ENSG00000086570 | HGNC:HGNC:3596 | PA28009 | 5q33.1 |
GO terms in FAT2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005634 | nucleus |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005913 | cell-cell adherens junction |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | ISS | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | IMP | GO:0010631 | epithelial cell migration |
| MF | IEA | GO:0005509 | calcium ion binding |
Gene expression in normal tissue: FAT2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FAT2
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FAT2
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