FCER1G
Summary: The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Fc fragment of IgE receptor Ig | MIM:147139 | Ensembl:ENSG00000158869 | HGNC:HGNC:3611 | PA28057 | 1q23.3 |
GO terms in FCER1G
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001798 | positive regulation of type IIa hypersensitivity |
| BP | IEA | GO:0001805 | positive regulation of type III hypersensitivity |
| BP | IEA | GO:0001812 | positive regulation of type I hypersensitivity |
| BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| BP | IBA | GO:0002283 | neutrophil activation involved in immune response |
| BP | IBA | GO:0002292 | T cell differentiation involved in immune response |
| BP | IBA | GO:0002431 | Fc receptor mediated stimulatory signaling pathway |
| BP | IEA | GO:0002554 | serotonin secretion by platelet |
| BP | IEA | GO:0006911 | phagocytosis, engulfment |
| BP | IEA | GO:0007229 | integrin-mediated signaling pathway |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IBA | GO:0010543 | regulation of platelet activation |
| BP | IBA | GO:0016064 | immunoglobulin mediated immune response |
| BP | IBA | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IEA | GO:0030316 | osteoclast differentiation |
| BP | IBA | GO:0030593 | neutrophil chemotaxis |
| BP | ISS | GO:0031623 | receptor internalization |
| BP | IEA | GO:0032623 | interleukin-2 production |
| BP | IEA | GO:0032733 | positive regulation of interleukin-10 production |
| BP | ISS | GO:0032753 | positive regulation of interleukin-4 production |
| BP | IEA | GO:0032755 | positive regulation of interleukin-6 production |
| BP | IEA | GO:0032760 | positive regulation of tumor necrosis factor production |
| BP | IEA | GO:0032765 | positive regulation of mast cell cytokine production |
| BP | IEA | GO:0033026 | negative regulation of mast cell apoptotic process |
| BP | IBA | GO:0038094 | Fc-gamma receptor signaling pathway |
| BP | IMP | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | ISS | GO:0038156 | interleukin-3-mediated signaling pathway |
| BP | IBA | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I |
| BP | IBA | GO:0042742 | defense response to bacterium |
| BP | IEA | GO:0043306 | positive regulation of mast cell degranulation |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IBA | GO:0045087 | innate immune response |
| BP | IEA | GO:0045576 | mast cell activation |
| BP | IBA | GO:0050766 | positive regulation of phagocytosis |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IMP | GO:0051260 | protein homooligomerization |
| BP | ISS | GO:0071404 | cellular response to low-density lipoprotein particle stimulus |
| BP | IEA | GO:0072659 | protein localization to plasma membrane |
| BP | IEA | GO:2000010 | positive regulation of protein localization to cell surface |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IBA | GO:0032998 | Fc-epsilon receptor I complex |
| CC | TAS | GO:0070821 | tertiary granule membrane |
| CC | TAS | GO:0101003 | ficolin-1-rich granule membrane |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0019767 | IgE receptor activity |
| MF | IBA | GO:0019863 | IgE binding |
| MF | IBA | GO:0019864 | IgG binding |
| MF | IMP | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: FCER1G
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FCER1G
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization |
| reactome | R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization |
| reactome | R-HSA-2871796 | FCERI mediated MAPK activation |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-2871809 | FCERI mediated Ca+2 mobilization |
| reactome | R-HSA-2871837 | FCERI mediated NF-kB activation |
| reactome | R-HSA-5621480 | Dectin-2 family |
| reactome | R-HSA-5621480 | Dectin-2 family |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-75892 | Platelet Adhesion to exposed collagen |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| biocarta | fcer1pathway | fc epsilon receptor i signaling in mast cells |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05310 | Asthma - Homo sapiens (human) |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| wikipathways | WP3937 | Microglia Pathogen Phagocytosis Pathway |
| smpdb | SMP00358 | Fc Epsilon Receptor I Signaling in Mast Cells |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FCER1G
CLASSFICATION
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