FCGR1A
Summary: This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Fc fragment of IgG receptor Ia | MIM:146760 | Ensembl:ENSG00000150337 | HGNC:HGNC:3613 | PA28060 | 1q21.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in FCGR1A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| BP | TAS | GO:0006898 | receptor-mediated endocytosis |
| BP | TAS | GO:0006911 | phagocytosis, engulfment |
| BP | TAS | GO:0006955 | immune response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | TAS | GO:0050776 | regulation of immune response |
| BP | TAS | GO:0060333 | interferon-gamma-mediated signaling pathway |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | TAS | GO:0030669 | clathrin-coated endocytic vesicle membrane |
| CC | TAS | GO:0031901 | early endosome membrane |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0019864 | IgG binding |
Gene expression in normal tissue: FCGR1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FCGR1A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05150 | Staphylococcus aureus infection - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05322 | Systemic lupus erythematosus - Homo sapiens (human) |
| wikipathways | WP3937 | Microglia Pathogen Phagocytosis Pathway |
| reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
| reactome | R-HSA-1236975 | Antigen processing-Cross presentation |
| reactome | R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) |
| reactome | R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029481 | FCGR activation |
| reactome | R-HSA-2029481 | FCGR activation |
| reactome | R-HSA-2029482 | Regulation of actin dynamics for phagocytic cup formation |
| reactome | R-HSA-2029485 | Role of phospholipids in phagocytosis |
| reactome | R-HSA-877300 | Interferon gamma signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FCGR1A
CLASSFICATION
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