FCGR3B


Summary: The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

Gene Categories:

DRUGGABLE GENOME

GO terms in FCGR3B


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0006955 immune response
BP TAS GO:0043312 neutrophil degranulation
CC TAS GO:0005576 extracellular region
CC TAS GO:0005886 plasma membrane
CC TAS GO:0030667 secretory granule membrane
CC IEA GO:0031225 anchored component of membrane
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Gene expression in normal tissue: FCGR3B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Breast cancer1

Pathways in FCGR3B


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Database
Pathway ID
Pathway Des.
kegg hsa04145 Phagosome - Homo sapiens (human)
kegg hsa04380 Osteoclast differentiation - Homo sapiens (human)
kegg hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegg hsa05140 Leishmaniasis - Homo sapiens (human)
kegg hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
kegg hsa05152 Tuberculosis - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD1020 Trastuzumab 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FCGR3B

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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