FCGR3B
Summary: The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:610665 Ensembl IDEnsembl:ENSG00000162747 HGNC IDHGNC:HGNC:3620 PHARMGKB IDPA28066 Map Location1q23.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in FCGR3B
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | TAS | GO:0006955 | immune response |
BP | TAS | GO:0043312 | neutrophil degranulation |
CC | TAS | GO:0005576 | extracellular region |
CC | TAS | GO:0005886 | plasma membrane |
CC | TAS | GO:0030667 | secretory granule membrane |
CC | IEA | GO:0031225 | anchored component of membrane |
Gene expression in normal tissue: FCGR3B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FCGR3B
Loading, please wait...
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa04145 | Phagosome - Homo sapiens (human) |
kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
kegg | hsa05150 | Staphylococcus aureus infection - Homo sapiens (human) |
kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
Loading, please wait...
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD1020 | Trastuzumab | 1 |
Showing 1 to 1 of 1 rows
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in FCGR3B
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |