GPC2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glypican 2 | Ensembl:ENSG00000213420 | HGNC:HGNC:4450 | PA28831 | 7q22.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in GPC2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005796 | Golgi lumen |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0043202 | lysosomal lumen |
| CC | IEA | GO:0046658 | anchored component of plasma membrane |
| CC | IEA | GO:0062023 | collagen-containing extracellular matrix |
| BP | TAS | GO:0001523 | retinoid metabolic process |
| BP | TAS | GO:0006024 | glycosaminoglycan biosynthetic process |
| BP | TAS | GO:0006027 | glycosaminoglycan catabolic process |
| BP | IEA | GO:0007224 | smoothened signaling pathway |
| BP | IEA | GO:0009966 | regulation of signal transduction |
| BP | IEA | GO:0030182 | neuron differentiation |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: GPC2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GPC2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | glypican_2pathway | Glypican 2 network |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
| reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
| reactome | R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism |
| reactome | R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-1971475 | A tetrasaccharide linker sequence is required for GAG synthesis |
| reactome | R-HSA-2022928 | HS-GAG biosynthesis |
| reactome | R-HSA-2022928 | HS-GAG biosynthesis |
| reactome | R-HSA-2024096 | HS-GAG degradation |
| reactome | R-HSA-2187338 | Visual phototransduction |
| reactome | R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism |
| reactome | R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type |
| reactome | R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD |
| reactome | R-HSA-3656237 | Defective EXT2 causes exostoses 2 |
| reactome | R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-3781865 | Diseases of glycosylation |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 |
| reactome | R-HSA-6806667 | Metabolism of fat-soluble vitamins |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| reactome | R-HSA-975634 | Retinoid metabolism and transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GPC2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.