LHFPL5


Summary: This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in this gene result in deafness in humans, and a mutation in a similar gene in mice results in deafness and vestibular dysfunction with severe degeneration of the organ of Corti. It is proposed to function in hair bundle morphogenesis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
LHFPL tetraspan subfamily member 5MIM:609427Ensembl:ENSG00000197753HGNC:HGNC:21253PA1349433896p21.31

GO terms in LHFPL5


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0016021integral component of membrane
CCIEAGO:0016324apical plasma membrane
CCIEAGO:0032426stereocilium tip
BPIEAGO:0006811ion transport
BPIEAGO:0050910detection of mechanical stimulus involved in sensory perception of sound
BPIEAGO:0060088auditory receptor cell stereocilium organization
MFIPIGO:0005515protein binding

Gene expression in normal tissue: LHFPL5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LHFPL5


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LHFPL5

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