ALDH3A2
Summary: Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:609523 Ensembl IDEnsembl:ENSG00000072210 HGNC IDHGNC:HGNC:403 PHARMGKB IDPA24698 Map Location17p11.2 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in ALDH3A2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity |
| MF | EXP | GO:0004029 | aldehyde dehydrogenase (NAD) activity |
| MF | IDA | GO:0004029 | aldehyde dehydrogenase (NAD) activity |
| MF | IMP | GO:0004029 | aldehyde dehydrogenase (NAD) activity |
| MF | TAS | GO:0004029 | aldehyde dehydrogenase (NAD) activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: ALDH3A2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ALDH3A2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00010 | Glycolysis / Gluconeogenesis - Homo sapiens (human) |
| kegg | hsa00053 | Ascorbate and aldarate metabolism - Homo sapiens (human) |
| kegg | hsa00071 | Fatty acid degradation - Homo sapiens (human) |
| kegg | hsa00280 | Valine, leucine and isoleucine degradation - Homo sapiens (human) |
| kegg | hsa00310 | Lysine degradation - Homo sapiens (human) |
| kegg | hsa00330 | Arginine and proline metabolism - Homo sapiens (human) |
Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD309 | 17AAG | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ALDH3A2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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