Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

fibroblast growth factor 12MIM:601513Ensembl:ENSG00000114279HGNC:HGNC:3668PA281083q28-q29

GO terms in FGF12

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0003254regulation of membrane depolarization
BPTASGO:0007165signal transduction
BPTASGO:0007267cell-cell signaling
BPIEAGO:0007268chemical synaptic transmission
BPTASGO:0007399nervous system development
BPTASGO:0007507heart development
BPIEAGO:0008344adult locomotory behavior
BPIEAGO:0008543fibroblast growth factor receptor signaling pathway
BPIEAGO:0010469regulation of signaling receptor activity
BPIEAGO:0010765positive regulation of sodium ion transport
BPIEAGO:0050905neuromuscular process
BPNASGO:0086002cardiac muscle cell action potential involved in contraction
BPIMPGO:0098908regulation of neuronal action potential
BPISSGO:1902305regulation of sodium ion transmembrane transport
BPIMPGO:1905150regulation of voltage-gated sodium channel activity
BPISSGO:2000649regulation of sodium ion transmembrane transporter activity
BPIEAGO:2001258negative regulation of cation channel activity
CCTASGO:0005615extracellular space
MFIPIGO:0005515protein binding
MFIEAGO:0008083growth factor activity
MFISSGO:0017080sodium channel regulator activity
MFISSGO:0044325ion channel binding

Gene expression in normal tissue: FGF12

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FGF12

DatabasePathway IDPathway Des.
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5576892Phase 0 - rapid depolarisation
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FGF12