FGF14


Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].

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GO terms in FGF14


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0007165 signal transduction
BP TAS GO:0007267 cell-cell signaling
BP IEA GO:0007399 nervous system development
BP IEA GO:0010469 regulation of signaling receptor activity
BP IEA GO:0048167 regulation of synaptic plasticity
BP IEA GO:0060078 regulation of postsynaptic membrane potential
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Gene expression in normal tissue: FGF14

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Protein stability and degradation1

Pathways in FGF14


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Database
Pathway ID
Pathway Des.
wikipathways WP382 MAPK Signaling Pathway
wikipathways WP3931 ESC Pluripotency Pathways
wikipathways WP3932 Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways WP4172 PI3K-Akt Signaling Pathway
wikipathways WP51 Regulation of Actin Cytoskeleton
reactome R-HSA-397014 Muscle contraction
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FGF14

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Cancer
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