Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].

fibroblast growth factor 14MIM:601515Ensembl:ENSG00000102466HGNC:HGNC:3671PA2811013q33.1

GO terms in FGF14

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0007165signal transduction
BPTASGO:0007267cell-cell signaling
BPIEAGO:0007399nervous system development
BPIEAGO:0010469regulation of signaling receptor activity
BPIEAGO:0048167regulation of synaptic plasticity
BPIEAGO:0060078regulation of postsynaptic membrane potential
BPIEAGO:1901843positive regulation of high voltage-gated calcium channel activity
BPIEAGO:1903421regulation of synaptic vesicle recycling
CCIEAGO:0005576extracellular region
MFIPIGO:0005515protein binding
MFIEAGO:0008083growth factor activity

Gene expression in normal tissue: FGF14

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FGF14

DatabasePathway IDPathway Des.
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5576892Phase 0 - rapid depolarisation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FGF14