FGF14
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| fibroblast growth factor 14 | MIM:601515 | Ensembl:ENSG00000102466 | HGNC:HGNC:3671 | PA28110 | 13q33.1 |
GO terms in FGF14
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | IEA | GO:0007399 | nervous system development |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0048167 | regulation of synaptic plasticity |
| BP | IEA | GO:0060078 | regulation of postsynaptic membrane potential |
| BP | IEA | GO:1901843 | positive regulation of high voltage-gated calcium channel activity |
| BP | IEA | GO:1903421 | regulation of synaptic vesicle recycling |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IEA | GO:0005634 | nucleus |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008083 | growth factor activity |
Gene expression in normal tissue: FGF14
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FGF14
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5576892 | Phase 0 - rapid depolarisation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FGF14
CLASSFICATION
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