CASC3


Summary: The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
CASC3, exon junction complex subunitMIM:606504Ensembl:ENSG00000108349HGNC:HGNC:17040PA13494859617q21.1

GO terms in CASC3


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIPIGO:0019899enzyme binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIDAGO:0042802identical protein binding
BPTASGO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
BPTASGO:0000398mRNA splicing, via spliceosome
BPTASGO:0006405RNA export from nucleus
BPTASGO:0006406mRNA export from nucleus
BPIEAGO:0006417regulation of translation
BPNDGO:0008150biological_process
BPIEAGO:0008298intracellular mRNA localization
BPIBAGO:0016070RNA metabolic process
BPTASGO:0031124mRNA 3'-end processing
CCTASGO:0005654nucleoplasm
CCTASGO:0005829cytosol
CCIEAGO:0010494cytoplasmic stress granule
CCIEAGO:0016607nuclear speck
CCIEAGO:0030425dendrite
CCIDAGO:0031965nuclear membrane
CCIBAGO:0035145exon-exon junction complex
CCIDAGO:0035145exon-exon junction complex
CCIEAGO:0048471perinuclear region of cytoplasm

Gene expression in normal tissue: CASC3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CASC3


DatabasePathway IDPathway Des.
reactomeR-HSA-109688Cleavage of Growing Transcript in the Termination Region
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-159236Transport of Mature mRNA derived from an Intron-Containing Transcript
reactomeR-HSA-376176Signaling by ROBO receptors
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-72163mRNA Splicing - Major Pathway
reactomeR-HSA-72172mRNA Splicing
reactomeR-HSA-72187mRNA 3'-end processing
reactomeR-HSA-72202Transport of Mature Transcript to Cytoplasm
reactomeR-HSA-72203Processing of Capped Intron-Containing Pre-mRNA
reactomeR-HSA-73856RNA Polymerase II Transcription Termination
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-9010553Regulation of expression of SLITs and ROBOs
reactomeR-HSA-927802Nonsense-Mediated Decay (NMD)
reactomeR-HSA-975957Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
kegghsa03013RNA transport - Homo sapiens (human)
kegghsa03015mRNA surveillance pathway - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CASC3

​​​​