LMTK2


Summary: The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
lemur tyrosine kinase 2MIM:610989Ensembl:ENSG00000164715HGNC:HGNC:17880PA1348843917q21.3

GO terms in LMTK2


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0001881receptor recycling
BPIBAGO:0001934positive regulation of protein phosphorylation
BPIDAGO:0006468protein phosphorylation
BPIBAGO:0007275multicellular organism development
BPIBAGO:0009968negative regulation of signal transduction
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0018107peptidyl-threonine phosphorylation
BPIBAGO:0030154cell differentiation
BPIMPGO:0032456endocytic recycling
BPIEAGO:0032515negative regulation of phosphoprotein phosphatase activity
BPIMPGO:0033572transferrin transport
BPIBAGO:0033674positive regulation of kinase activity
BPIBAGO:0043066negative regulation of apoptotic process
BPIMPGO:0045022early endosome to late endosome transport
BPIDAGO:0046777protein autophosphorylation
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
CCIBAGO:0005737cytoplasm
CCIDAGO:0005769early endosome
CCIDAGO:0005794Golgi apparatus
CCIEAGO:0005829cytosol
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0016021integral component of membrane
CCIEAGO:0030426growth cone
CCIEAGO:0043025neuronal cell body
CCIBAGO:0043235receptor complex
CCIDAGO:0048471perinuclear region of cytoplasm
CCIDAGO:0055037recycling endosome
MFIDAGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIDAGO:0004864protein phosphatase inhibitor activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIPIGO:0005515protein binding
MFNASGO:0005524ATP binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFIPIGO:0070853myosin VI binding

Gene expression in normal tissue: LMTK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LMTK2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD85Ursolic acid3
iGMDRD698Neratinib3
iGMDRD211(1S,3R)-RSL32
iGMDRD901ELCPK1
iGMDRD177Teniposide2
iGMDRD154NSC237663
iGMDRD84Lovastatin acid3
iGMDRD512nutlin 35
iGMDRD522ML-0303
iGMDRD424Tamatinib5
iGMDRD523Cyanoquinoline, 113
iGMDRD79Gemcitabine4
iGMDRD871BRD63682
iGMDRD882CIL412
iGMDRD329Merck603
iGMDRD300Tozasertib1
iGMDRD137Indisulam3
iGMDRD202Curcumin3
iGMDRD158NSC1415401
iGMDRD5Tyrphostin AG 14783
iGMDRD434BMS-5369242
iGMDRD77Itraconazole3
iGMDRD213SMR0000686502
iGMDRD152179324-69-72
iGMDRD193Fqi14
iGMDRD61Kinetin riboside4
iGMDRD394BX-7953
iGMDRD126Tipifarnib9
iGMDRD1008SR-II-138A2
iGMDRD670ML 2104
iGMDRD144NSC953973
iGMDRD781Sirolimus3
iGMDRD506Fedratinib2
iGMDRD562Navitoclax2
iGMDRD398Sepantronium6
iGMDRD780PP-303
iGMDRD369TGX-1153
iGMDRD874BRD89582
iGMDRD474Avrainvillamide2
iGMDRD8024-methylfasudil1
iGMDRD782DC-45-A22
iGMDRD885Compound 1103

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LMTK2

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