LMTK2
Summary: The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lemur tyrosine kinase 2 | MIM:610989 | Ensembl:ENSG00000164715 | HGNC:HGNC:17880 | PA134884391 | 7q21.3 |
GO terms in LMTK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0001881 | receptor recycling |
| BP | IBA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IMP | GO:0032456 | endocytic recycling |
| BP | IEA | GO:0032515 | negative regulation of phosphoprotein phosphatase activity |
| BP | IMP | GO:0033572 | transferrin transport |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0045022 | early endosome to late endosome transport |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005769 | early endosome |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0005829 | cytosol |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0030426 | growth cone |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IDA | GO:0055037 | recycling endosome |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IDA | GO:0004864 | protein phosphatase inhibitor activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0005524 | ATP binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IPI | GO:0070853 | myosin VI binding |
Gene expression in normal tissue: LMTK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LMTK2
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD522 | ML-030 | 3 |
| iGMDRD424 | Tamatinib | 5 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD126 | Tipifarnib | 9 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD670 | ML 210 | 4 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD398 | Sepantronium | 6 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD874 | BRD8958 | 2 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD802 | 4-methylfasudil | 1 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD885 | Compound 110 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LMTK2
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