Summary: The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].

SEC31 homolog A, COPII coat complex componentMIM:610257Ensembl:ENSG00000138674HGNC:HGNC:17052PA1624027374q21.22

GO terms in SEC31A

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005198structural molecule activity
MFIPIGO:0005515protein binding
MFIPIGO:0048306calcium-dependent protein binding
CCIEAGO:0000139Golgi membrane
CCIDAGO:0005783endoplasmic reticulum
CCTASGO:0005789endoplasmic reticulum membrane
CCTASGO:0012507ER to Golgi transport vesicle membrane
CCIDAGO:0030120vesicle coat
CCIBAGO:0030127COPII vesicle coat
CCIDAGO:0030127COPII vesicle coat
CCNASGO:0030127COPII vesicle coat
CCIDAGO:0030134COPII-coated ER to Golgi transport vesicle
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIDAGO:0048471perinuclear region of cytoplasm
CCIBAGO:0070971endoplasmic reticulum exit site
CCIMPGO:0070971endoplasmic reticulum exit site
BPTASGO:0002474antigen processing and presentation of peptide antigen via MHC class I
BPIBAGO:0006886intracellular protein transport
BPIBAGO:0006888ER to Golgi vesicle-mediated transport
BPNASGO:0006888ER to Golgi vesicle-mediated transport
BPIBAGO:0007029endoplasmic reticulum organization
BPIEAGO:0015031protein transport
BPTASGO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II
BPTASGO:0036498IRE1-mediated unfolded protein response
BPTASGO:0048208COPII vesicle coating
BPIDAGO:0051592response to calcium ion
BPIBAGO:0090110cargo loading into COPII-coated vesicle
BPIDAGO:0090110cargo loading into COPII-coated vesicle
BPIBAGO:0090114COPII-coated vesicle budding

Gene expression in normal tissue: SEC31A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SEC31A

DatabasePathway IDPathway Des.
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
wikipathwaysWP1982Sterol Regulatory Element-Binding Proteins (SREBP) signalling
wikipathwaysWP3472XBP1(S) activates chaperone genes
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-199977ER to Golgi Anterograde Transport
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-204005COPII-mediated vesicle transport
reactomeR-HSA-2132295MHC class II antigen presentation
reactomeR-HSA-381038XBP1(S) activates chaperone genes
reactomeR-HSA-381070IRE1alpha activates chaperones
reactomeR-HSA-381119Unfolded Protein Response (UPR)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-948021Transport to the Golgi and subsequent modification
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
reactomeR-HSA-983170Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SEC31A