SEC31A


Summary: The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].

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GO terms in SEC31A


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0005198 structural molecule activity
MF IPI GO:0005515 protein binding
MF IPI GO:0048306 calcium-dependent protein binding
CC IEA GO:0000139 Golgi membrane
CC IDA GO:0005737 cytoplasm
CC IDA GO:0005783 endoplasmic reticulum
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Gene expression in normal tissue: SEC31A

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

Pathways in SEC31A


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Database
Pathway ID
Pathway Des.
kegg hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
wikipathways WP1982 Sterol Regulatory Element-Binding Proteins (SREBP) signalling
wikipathways WP3472 XBP1(S) activates chaperone genes
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-199977 ER to Golgi Anterograde Transport
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD68 Paclitaxel 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SEC31A

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Model
Level
Reference ID
Tissue
Cancer
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Source
No matching records found

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