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SEPHS1

Summary: This gene encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons. [provided by RefSeq, Sep 2010].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
selenophosphate synthetase 1	MIM:600902	Ensembl:ENSG00000086475	HGNC:HGNC:19685	PA134905215	10p13

Gene Categories:

KINASE

GO terms in SEPHS1

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0001887	selenium compound metabolic process
BP	TAS	GO:0006464	cellular protein modification process
BP	IBA	GO:0016260	selenocysteine biosynthetic process
BP	IEA	GO:0016260	selenocysteine biosynthetic process
BP	IEA	GO:0016310	phosphorylation
BP	IBA	GO:0070329	tRNA seleno-modification
CC	IBA	GO:0005737	cytoplasm
CC	IEA	GO:0005737	cytoplasm
CC	IEA	GO:0005886	plasma membrane
CC	IEA	GO:0031965	nuclear membrane
MF	IBA	GO:0004756	selenide, water dikinase activity
MF	IEA	GO:0004756	selenide, water dikinase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	TAS	GO:0005525	GTP binding
MF	IPI	GO:0042802	identical protein binding

Gene expression in normal tissue: SEPHS1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SEPHS1

Database	Pathway ID	Pathway Des.
kegg	hsa00450	Selenocompound metabolism - Homo sapiens (human)
humancyc	PWY-6281	selenocysteine biosynthesis

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SEPHS1

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DATATYPES

CLASSFICATION

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