PTGR1
Summary: This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
prostaglandin reductase 1 | MIM:601274 | Ensembl:ENSG00000106853 | HGNC:HGNC:18429 | PA162400322 | 9q31.3 |
GO terms in PTGR1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IEA | GO:0005737 | cytoplasm |
CC | HDA | GO:0070062 | extracellular exosome |
BP | NAS | GO:0006691 | leukotriene metabolic process |
BP | IEA | GO:0006693 | prostaglandin metabolic process |
BP | IEA | GO:0055114 | oxidation-reduction process |
BP | IEA | GO:0097327 | response to antineoplastic agent |
MF | IEA | GO:0032440 | 2-alkenal reductase [NAD(P)] activity |
MF | IEA | GO:0036132 | 13-prostaglandin reductase activity |
MF | IEA | GO:0047522 | 15-oxoprostaglandin 13-oxidase activity |
Gene expression in normal tissue: PTGR1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTGR1
Database | Pathway ID | Pathway Des. |
---|---|---|
humancyc | PWY3DJ-11470 | sphingosine and sphingosine-1-phosphate metabolism |
wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
wikipathways | WP2884 | NRF2 pathway |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) |
reactome | R-HSA-2142700 | Synthesis of Lipoxins (LX) |
reactome | R-HSA-2142753 | Arachidonic acid metabolism |
reactome | R-HSA-556833 | Metabolism of lipids |
reactome | R-HSA-8978868 | Fatty acid metabolism |
reactome | R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) |
Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in PTGR1