SARM1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sterile alpha and TIR motif containing 1 | MIM:607732 | Ensembl:ENSG00000004139 | HGNC:HGNC:17074 | PA134971180 | 17q11.2 |
GO terms in SARM1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0005874 | microtubule |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0030424 | axon |
| CC | IBA | GO:0030425 | dendrite |
| CC | ISS | GO:0030425 | dendrite |
| CC | IEA | GO:0031315 | extrinsic component of mitochondrial outer membrane |
| CC | ISS | GO:0045202 | synapse |
| BP | IEA | GO:0009749 | response to glucose |
| BP | TAS | GO:0034128 | negative regulation of MyD88-independent toll-like receptor signaling pathway |
| BP | IEA | GO:0042981 | regulation of apoptotic process |
| BP | IEA | GO:0045087 | innate immune response |
| BP | ISS | GO:0048814 | regulation of dendrite morphogenesis |
| BP | IBA | GO:1901214 | regulation of neuron death |
| BP | ISS | GO:1901214 | regulation of neuron death |
Gene expression in normal tissue: SARM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SARM1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-936964 | Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| reactome | R-HSA-937041 | IKK complex recruitment mediated by RIP1 |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-937072 | TRAF6-mediated induction of TAK1 complex within TLR4 complex |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SARM1
CLASSFICATION
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