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RAP1GAP2

Summary: This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
RAP1 GTPase activating protein 2		Ensembl:ENSG00000132359	HGNC:HGNC:29176	PA165432528	17p13.3

GO terms in RAP1GAP2

Term Type	Evidence Type	GO Term ID	GO Des.
MF	EXP	GO:0005096	GTPase activator activity
MF	IPI	GO:0005515	protein binding
BP	IGI	GO:0008361	regulation of cell size
BP	IMP	GO:0008361	regulation of cell size
BP	IEA	GO:0010977	negative regulation of neuron projection development
BP	IEA	GO:0043547	positive regulation of GTPase activity
BP	IEA	GO:0051056	regulation of small GTPase mediated signal transduction
CC	IDA	GO:0005813	centrosome
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IGI	GO:0005886	plasma membrane
CC	IDA	GO:0031965	nuclear membrane
CC	IEA	GO:0043005	neuron projection
CC	IEA	GO:0048471	perinuclear region of cytoplasm

Gene expression in normal tissue: RAP1GAP2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RAP1GAP2

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1280218	Adaptive Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-392517	Rap1 signalling

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD309	17AAG	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RAP1GAP2

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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.