SEPT6


Summary: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:300683
PHARMGKB IDPA134941944
Map LocationXq24

Gene Categories:

CELL SURFACE

GO terms in SEPT6


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IEA GO:0000777 condensed chromosome kinetochore
CC IEA GO:0005819 spindle
CC IBA GO:0005940 septin ring
CC IEA GO:0005940 septin ring
CC IEA GO:0008021 synaptic vesicle
CC IBA GO:0015630 microtubule cytoskeleton
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Gene expression in normal tissue: SEPT6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SEPT6


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Database
Pathway ID
Pathway Des.
kegg hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SEPT6

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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