SEPT6
Summary: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameseptin 6 OMIM IDMIM:300683 Ensembl IDEnsembl:ENSG00000125354 HGNC IDHGNC:HGNC:15848 PHARMGKB IDPA134941944 Map LocationXq24 | |||||
Gene Categories:
CELL SURFACEGO terms in SEPT6
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0000777 | condensed chromosome kinetochore |
| CC | IEA | GO:0005819 | spindle |
| CC | IBA | GO:0005940 | septin ring |
| CC | IEA | GO:0005940 | septin ring |
| CC | IEA | GO:0008021 | synaptic vesicle |
| CC | IBA | GO:0015630 | microtubule cytoskeleton |
Gene expression in normal tissue: SEPT6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SEPT6
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SEPT6
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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