Summary: Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011].

fms related tyrosine kinase 3 ligandMIM:600007Ensembl:ENSG00000090554HGNC:HGNC:3766PA2818219q13.33

GO terms in FLT3LG

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIEAGO:0005615extracellular space
CCIBAGO:0009986cell surface
CCNASGO:0016021integral component of membrane
CCIEAGO:0031233intrinsic component of external side of plasma membrane
BPIEAGO:0001934positive regulation of protein phosphorylation
BPTASGO:0007165signal transduction
BPIBAGO:0008284positive regulation of cell proliferation
BPIDAGO:0008284positive regulation of cell proliferation
BPIEAGO:0010469regulation of signaling receptor activity
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0030098lymphocyte differentiation
BPIEAGO:0030885regulation of myeloid dendritic cell activation
BPIEAGO:0032819positive regulation of natural killer cell proliferation
BPIEAGO:0032825positive regulation of natural killer cell differentiation
BPIDAGO:0035162embryonic hemopoiesis
BPIEAGO:0045663positive regulation of myoblast differentiation
BPIEAGO:0045787positive regulation of cell cycle
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048873homeostasis of number of cells within a tissue
BPIEAGO:0071864positive regulation of cell proliferation in bone marrow
BPIEAGO:0071866negative regulation of apoptotic process in bone marrow
BPIEAGO:0090290positive regulation of osteoclast proliferation
BPIEAGO:1901741positive regulation of myoblast fusion
MFTASGO:0005102signaling receptor binding
MFIEAGO:0005125cytokine activity
MFIBAGO:0030971receptor tyrosine kinase binding
MFIEAGO:0030971receptor tyrosine kinase binding
MFIEAGO:0042803protein homodimerization activity

Gene expression in normal tissue: FLT3LG

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FLT3LG

DatabasePathway IDPathway Des.
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449836Other interleukin signaling
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP2848Differentiation Pathway
wikipathwaysWP3892Development of pulmonary dendritic cells and macrophage subsets
wikipathwaysWP4172PI3K-Akt Signaling Pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FLT3LG