OTUD3
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| OTU deubiquitinase 3 | MIM:611758 | Ensembl:ENSG00000169914 | HGNC:HGNC:29038 | PA142671215 | 1p36.13 |
Gene Categories:
PROTEASEGO terms in OTUD3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | IMP | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | TAS | GO:0004843 | thiol-dependent ubiquitin-specific protease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IDA | GO:0035871 | protein K11-linked deubiquitination |
| BP | IDA | GO:0044313 | protein K6-linked deubiquitination |
| BP | IDA | GO:0050821 | protein stabilization |
| BP | IMP | GO:0050821 | protein stabilization |
| BP | IDA | GO:0051898 | negative regulation of protein kinase B signaling |
| BP | IMP | GO:0051898 | negative regulation of protein kinase B signaling |
| BP | IDA | GO:0071108 | protein K48-linked deubiquitination |
| BP | IDA | GO:1990167 | protein K27-linked deubiquitination |
Gene expression in normal tissue: OTUD3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in OTUD3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689896 | Ovarian tumor domain proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-8948751 | Regulation of PTEN stability and activity |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in OTUD3
CLASSFICATION
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