ADGRL2
Summary: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| adhesion G protein-coupled receptor L2 | MIM:607018 | Ensembl:ENSG00000117114 | HGNC:HGNC:18582 | PA38589 | 1p31.1 |
GO terms in ADGRL2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007166 | cell surface receptor signaling pathway |
| BP | NAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0007420 | brain development |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0043005 | neuron projection |
| MF | IBA | GO:0001965 | G-protein alpha-subunit binding |
| MF | IBA | GO:0004930 | G-protein coupled receptor activity |
| MF | IEA | GO:0004930 | G-protein coupled receptor activity |
| MF | NAS | GO:0016524 | latrotoxin receptor activity |
| MF | IEA | GO:0030246 | carbohydrate binding |
Gene expression in normal tissue: ADGRL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADGRL2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP117 | GPCRs, Other |
| wikipathways | WP334 | GPCRs, Class B Secretin-like |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADGRL2
CLASSFICATION
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