ADGRL3
Summary: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| adhesion G protein-coupled receptor L3 | MIM:616417 | Ensembl:ENSG00000150471 | HGNC:HGNC:20974 | PA134968284 | 4q13.1 |
GO terms in ADGRL3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0001965 | G-protein alpha-subunit binding |
| MF | IBA | GO:0004930 | G-protein coupled receptor activity |
| MF | NAS | GO:0004930 | G-protein coupled receptor activity |
| MF | IDA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0030246 | carbohydrate binding |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0005911 | cell-cell junction |
| CC | ISS | GO:0005911 | cell-cell junction |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IBA | GO:0030424 | axon |
| CC | ISS | GO:0030424 | axon |
| BP | ISS | GO:0001764 | neuron migration |
| BP | IEA | GO:0007166 | cell surface receptor signaling pathway |
| BP | NAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0007416 | synapse assembly |
| BP | ISS | GO:0007416 | synapse assembly |
| BP | IBA | GO:0007420 | brain development |
| BP | IEA | GO:0031987 | locomotion involved in locomotory behavior |
| BP | IEA | GO:0042220 | response to cocaine |
| BP | IEA | GO:0051965 | positive regulation of synapse assembly |
| BP | IBA | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules |
| BP | IDA | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules |
Gene expression in normal tissue: ADGRL3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADGRL3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP117 | GPCRs, Other |
| wikipathways | WP334 | GPCRs, Class B Secretin-like |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADGRL3
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