Summary: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008].

adhesion G protein-coupled receptor L3MIM:616417Ensembl:ENSG00000150471HGNC:HGNC:20974PA1349682844q13.1

GO terms in ADGRL3

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0001965G-protein alpha-subunit binding
MFIBAGO:0004930G-protein coupled receptor activity
MFNASGO:0004930G-protein coupled receptor activity
MFIDAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIEAGO:0030246carbohydrate binding
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIBAGO:0005911cell-cell junction
CCISSGO:0005911cell-cell junction
CCNASGO:0016021integral component of membrane
BPISSGO:0001764neuron migration
BPIEAGO:0007166cell surface receptor signaling pathway
BPNASGO:0007186G-protein coupled receptor signaling pathway
BPIBAGO:0007416synapse assembly
BPISSGO:0007416synapse assembly
BPIBAGO:0007420brain development
BPIEAGO:0031987locomotion involved in locomotory behavior
BPIEAGO:0042220response to cocaine
BPIEAGO:0051965positive regulation of synapse assembly
BPIBAGO:0098742cell-cell adhesion via plasma-membrane adhesion molecules
BPIDAGO:0098742cell-cell adhesion via plasma-membrane adhesion molecules

Gene expression in normal tissue: ADGRL3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ADGRL3

DatabasePathway IDPathway Des.
wikipathwaysWP117GPCRs, Other
wikipathwaysWP334GPCRs, Class B Secretin-like

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADGRL3