HAUS5

Summary: HAUS5 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameHAUS augmin like complex subunit 5
OMIM IDMIM:613432
Ensembl IDEnsembl:ENSG00000249115
HGNC IDHGNC:HGNC:29130
PHARMGKB IDPA165393415
Map Location19q13.12

Gene Categories:

TUMOR SUPPRESSOR

GO terms in HAUS5


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ND GO:0003674 molecular_function
MF IPI GO:0005515 protein binding
BP TAS GO:0000086 G2/M transition of mitotic cell cycle
BP IMP GO:0007098 centrosome cycle
BP TAS GO:0010389 regulation of G2/M transition of mitotic cell cycle
BP IMP GO:0051225 spindle assembly
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Gene expression in normal tissue: HAUS5

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in HAUS5


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-1852241 Organelle biogenesis and maintenance
reactome R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
reactome R-HSA-380259 Loss of Nlp from mitotic centrosomes
reactome R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
reactome R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

KRASKRASZNF273ZNF273PAX5PAX5CCDC117CCDC117SLC16A3SLC16A3NPAS2NPAS2RXRARXRAZFP36L2ZFP36L2RNU2-11PRNU2-11PAPOC1APOC1TCF7L2TCF7L2ZNF682ZNF682BRAFBRAFWDR24WDR24FERMT1FERMT1NHLRC1NHLRC1ZNF736ZNF736RN7SL477PRN7SL477PNRASNRASKLHL32KLHL32PD0325901PD0325901HAUS5HAUS5

Gene-drug targets distribution

Gene Structure: PDB

Models in HAUS5

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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