SPECC1L


Summary: This gene encodes a coiled-coil domain containing protein. The encoded protein may play a critical role in actin-cytoskeletal reorganization during facial morphogenesis. Mutations in this gene are a cause of oblique facial clefting-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A read-through transcript composed of SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and the downstream ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013].

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GO terms in SPECC1L


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005815 microtubule organizing center
CC IEA GO:0005819 spindle
CC IDA GO:0005829 cytosol
CC IEA GO:0005921 gap junction
CC IDA GO:0015629 actin cytoskeleton
CC IBA GO:0031941 filamentous actin
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Gene expression in normal tissue: SPECC1L

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SPECC1L


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Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SPECC1L

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Cancer
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No matching records found

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