TARDBP
Summary: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TAR DNA binding protein | MIM:605078 | Ensembl:ENSG00000120948 | HGNC:HGNC:11571 | PA36336 | 1p36.22 |
Gene Categories:
TUMOR SUPPRESSORGO terms in TARDBP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005726 | perichromatin fibrils |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0016607 | nuclear speck |
| CC | IEA | GO:0035061 | interchromatin granule |
| BP | IMP | GO:0001933 | negative regulation of protein phosphorylation |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0006397 | mRNA processing |
| BP | IDA | GO:0008380 | RNA splicing |
| BP | IMP | GO:0010629 | negative regulation of gene expression |
| BP | IEA | GO:0032024 | positive regulation of insulin secretion |
| BP | IEA | GO:0034976 | response to endoplasmic reticulum stress |
| BP | IMP | GO:0042981 | regulation of apoptotic process |
| BP | IDA | GO:0043922 | negative regulation by host of viral transcription |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0051252 | regulation of RNA metabolic process |
| BP | IMP | GO:0051726 | regulation of cell cycle |
| BP | IBA | GO:0070935 | 3'-UTR-mediated mRNA stabilization |
| BP | IDA | GO:0070935 | 3'-UTR-mediated mRNA stabilization |
| BP | IMP | GO:0071765 | nuclear inner membrane organization |
| MF | IBA | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IEA | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IBA | GO:0003690 | double-stranded DNA binding |
| MF | IDA | GO:0003690 | double-stranded DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003727 | single-stranded RNA binding |
| MF | IBA | GO:0003730 | mRNA 3'-UTR binding |
| MF | IDA | GO:0003730 | mRNA 3'-UTR binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: TARDBP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TARDBP
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