CBX5
Summary: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| chromobox 5 | MIM:604478 | Ensembl:ENSG00000094916 | HGNC:HGNC:1555 | PA26130 | 12q13.13 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in CBX5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003682 | chromatin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0030674 | protein binding, bridging |
| MF | IDA | GO:0035064 | methylated histone binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0042826 | histone deacetylase binding |
| MF | IDA | GO:0043021 | ribonucleoprotein complex binding |
| MF | IDA | GO:0044877 | protein-containing complex binding |
| MF | ISS | GO:0070491 | repressing transcription factor binding |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IEA | GO:0016032 | viral process |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | TAS | GO:0070317 | negative regulation of G0 to G1 transition |
| CC | ISS | GO:0000118 | histone deacetylase complex |
| CC | IEA | GO:0000776 | kinetochore |
| CC | HDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005635 | nuclear envelope |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005720 | nuclear heterochromatin |
| CC | ISS | GO:0005721 | pericentric heterochromatin |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IEA | GO:0010369 | chromocenter |
| CC | IMP | GO:0016605 | PML body |
| CC | ISS | GO:0017053 | transcriptional repressor complex |
| CC | NAS | GO:0031618 | nuclear pericentric heterochromatin |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | ISS | GO:0035097 | histone methyltransferase complex |
| CC | IDA | GO:1990904 | ribonucleoprotein complex |
Gene expression in normal tissue: CBX5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CBX5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | aurora_b_pathway | Aurora B signaling |
| pid | e2f_pathway | E2F transcription factor network |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4551638 | SUMOylation of chromatin organization proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953750 | Transcriptional Regulation by E2F6 |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CBX5
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