BRD4
Summary: The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| bromodomain containing 4 | MIM:608749 | Ensembl:ENSG00000141867 | HGNC:HGNC:13575 | PA25416 | 19p13.12 |
GO terms in BRD4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000794 | condensed nuclear chromosome |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| BP | IMP | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle |
| BP | IEA | GO:0006325 | chromatin organization |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IMP | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle |
| BP | IEA | GO:0016032 | viral process |
| BP | IDA | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter |
| BP | IMP | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter |
| BP | IDA | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0050727 | regulation of inflammatory response |
| BP | IDA | GO:1901407 | regulation of phosphorylation of RNA polymerase II C-terminal domain |
| MF | IDA | GO:0000993 | RNA polymerase II core binding |
| MF | IDA | GO:0002039 | p53 binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0070577 | lysine-acetylated histone binding |
Gene expression in normal tissue: BRD4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BRD4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3295 | Chemical Compounds to monitor Proteins |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD887 | Compound 23 citrate | 6 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD207 | Capsaicin | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD126 | Tipifarnib | 7 |
| iGMDRD433 | Lexibulin | 1 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD511 | CHEMBL399379 | 2 |
| iGMDRD85 | Ursolic acid | 5 |
| iGMDRD499 | PDMP | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD424 | Tamatinib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BRD4
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