BRD4


Summary: The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
bromodomain containing 4MIM:608749Ensembl:ENSG00000141867HGNC:HGNC:13575PA2541619p13.12

GO terms in BRD4


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0000794condensed nuclear chromosome
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
BPIMPGO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle
BPIEAGO:0006325chromatin organization
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006974cellular response to DNA damage stimulus
BPIMPGO:0010971positive regulation of G2/M transition of mitotic cell cycle
BPIEAGO:0016032viral process
BPIDAGO:0032968positive regulation of transcription elongation from RNA polymerase II promoter
BPIMPGO:0032968positive regulation of transcription elongation from RNA polymerase II promoter
BPIDAGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0050727regulation of inflammatory response
BPIDAGO:1901407regulation of phosphorylation of RNA polymerase II C-terminal domain
MFIDAGO:0000993RNA polymerase II core binding
MFIDAGO:0002039p53 binding
MFIDAGO:0003682chromatin binding
MFIPIGO:0005515protein binding
MFIDAGO:0070577lysine-acetylated histone binding

Gene expression in normal tissue: BRD4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BRD4


DatabasePathway IDPathway Des.
wikipathwaysWP3295Chemical Compounds to monitor Proteins

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD64Parbendazole3
iGMDRD60Quinoclamine2
iGMDRD369TGX-1153
iGMDRD356PNU-746543
iGMDRD887Compound 23 citrate6
iGMDRD577BIX012942
iGMDRD780PP-303
iGMDRD207Capsaicin1
iGMDRD782DC-45-A23
iGMDRD226ML0062
iGMDRD187BRD98763
iGMDRD294Batimastat1
iGMDRD297Austocystin D2
iGMDRD394BX-7953
iGMDRD446LY 21832404
iGMDRD781Sirolimus5
iGMDRD126Tipifarnib7
iGMDRD433Lexibulin1
iGMDRD889Compound 7d-cis3
iGMDRD579PF7502
iGMDRD300Tozasertib3
iGMDRD367Ro 28-16753
iGMDRD871BRD63683
iGMDRD414MST-3123
iGMDRD872BRD71373
iGMDRD269Purmorphamine2
iGMDRD6AM-5803
iGMDRD158NSC1415403
iGMDRD137Indisulam1
iGMDRD901ELCPK3
iGMDRD154NSC237664
iGMDRD511CHEMBL3993792
iGMDRD85Ursolic acid5
iGMDRD499PDMP2
iGMDRD351GW843682X3
iGMDRD424Tamatinib3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BRD4

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