FOLR1
Summary: The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| folate receptor 1 | MIM:136430 | Ensembl:ENSG00000110195 | HGNC:HGNC:3791 | PA28207 | 11q13.4 |
GO terms in FOLR1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005542 | folic acid binding |
| MF | IDA | GO:0005542 | folic acid binding |
| MF | NAS | GO:0005542 | folic acid binding |
| MF | IPI | GO:0008144 | drug binding |
| MF | TAS | GO:0038023 | signaling receptor activity |
| MF | IDA | GO:0051870 | methotrexate binding |
| MF | IC | GO:0061714 | folic acid receptor activity |
| MF | IMP | GO:0061714 | folic acid receptor activity |
| BP | ISS | GO:0001947 | heart looping |
| BP | ISS | GO:0003147 | neural crest cell migration involved in heart formation |
| BP | ISS | GO:0003253 | cardiac neural crest cell migration involved in outflow tract morphogenesis |
| BP | TAS | GO:0006888 | ER to Golgi vesicle-mediated transport |
| BP | TAS | GO:0006898 | receptor-mediated endocytosis |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IMP | GO:0015884 | folic acid transport |
| BP | ISS | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway |
| BP | ISS | GO:0031103 | axon regeneration |
| BP | IEA | GO:0046655 | folic acid metabolic process |
| BP | TAS | GO:0048208 | COPII vesicle coating |
| BP | ISS | GO:0060828 | regulation of canonical Wnt signaling pathway |
| BP | ISS | GO:0061626 | pharyngeal arch artery morphogenesis |
| BP | ISS | GO:0061713 | anterior neural tube closure |
| BP | IDA | GO:0071231 | cellular response to folic acid |
| BP | IEA | GO:1904447 | folate import across plasma membrane |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | IDA | GO:0005634 | nucleus |
| CC | IEA | GO:0005768 | endosome |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | NAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0009986 | cell surface |
| CC | TAS | GO:0012507 | ER to Golgi transport vesicle membrane |
| CC | TAS | GO:0016020 | membrane |
| CC | IDA | GO:0016323 | basolateral plasma membrane |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | TAS | GO:0030133 | transport vesicle |
| CC | IEA | GO:0030136 | clathrin-coated vesicle |
| CC | IBA | GO:0031362 | anchored component of external side of plasma membrane |
| CC | IDA | GO:0031362 | anchored component of external side of plasma membrane |
| CC | IEA | GO:0031526 | brush border membrane |
| CC | TAS | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: FOLR1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FOLR1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-199977 | ER to Golgi Anterograde Transport |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-204005 | COPII-mediated vesicle transport |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5694530 | Cargo concentration in the ER |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6807878 | COPI-mediated anterograde transport |
| reactome | R-HSA-948021 | Transport to the Golgi and subsequent modification |
| pharmgkb | PA165816349 | Methotrexate Pathway, Pharmacokinetics |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| wikipathways | WP176 | Folate Metabolism |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FOLR1
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