Summary: The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009].

folate receptor 1MIM:136430Ensembl:ENSG00000110195HGNC:HGNC:3791PA2820711q13.4

GO terms in FOLR1

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005542folic acid binding
MFIDAGO:0005542folic acid binding
MFNASGO:0005542folic acid binding
MFIPIGO:0008144drug binding
MFTASGO:0038023signaling receptor activity
MFIDAGO:0051870methotrexate binding
MFICGO:0061714folic acid receptor activity
MFIMPGO:0061714folic acid receptor activity
BPISSGO:0001947heart looping
BPISSGO:0003147neural crest cell migration involved in heart formation
BPISSGO:0003253cardiac neural crest cell migration involved in outflow tract morphogenesis
BPTASGO:0006888ER to Golgi vesicle-mediated transport
BPTASGO:0006898receptor-mediated endocytosis
BPIEAGO:0007165signal transduction
BPIMPGO:0015884folic acid transport
BPISSGO:0017015regulation of transforming growth factor beta receptor signaling pathway
BPISSGO:0031103axon regeneration
BPIEAGO:0046655folic acid metabolic process
BPTASGO:0048208COPII vesicle coating
BPISSGO:0060828regulation of canonical Wnt signaling pathway
BPISSGO:0061626pharyngeal arch artery morphogenesis
BPISSGO:0061713anterior neural tube closure
BPIDAGO:0071231cellular response to folic acid
BPIEAGO:1904447folate import across plasma membrane
CCTASGO:0000139Golgi membrane
CCTASGO:0005789endoplasmic reticulum membrane
CCNASGO:0005886plasma membrane
CCHDAGO:0009986cell surface
CCTASGO:0012507ER to Golgi transport vesicle membrane
CCIDAGO:0016323basolateral plasma membrane
CCIDAGO:0016324apical plasma membrane
CCTASGO:0030133transport vesicle
CCIEAGO:0030136clathrin-coated vesicle
CCIBAGO:0031362anchored component of external side of plasma membrane
CCIDAGO:0031362anchored component of external side of plasma membrane
CCIEAGO:0031526brush border membrane
CCTASGO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: FOLR1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FOLR1

DatabasePathway IDPathway Des.
reactomeR-HSA-199977ER to Golgi Anterograde Transport
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-204005COPII-mediated vesicle transport
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5694530Cargo concentration in the ER
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6807878COPI-mediated anterograde transport
reactomeR-HSA-948021Transport to the Golgi and subsequent modification
pharmgkbPA165816349Methotrexate Pathway, Pharmacokinetics
kegghsa04144Endocytosis - Homo sapiens (human)
wikipathwaysWP176Folate Metabolism
wikipathwaysWP4180Ebola Virus Pathway on Host
wikipathwaysWP4217Ebola Virus Pathway on Host

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FOLR1