KAT6B
Summary: The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lysine acetyltransferase 6B | MIM:605880 | Ensembl:ENSG00000156650 | HGNC:HGNC:17582 | PA134880712 | 10q22.2 |
GO terms in KAT6B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0000123 | histone acetyltransferase complex |
| CC | NAS | GO:0000786 | nucleosome |
| CC | IBA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex |
| CC | IBA | GO:0070776 | MOZ/MORF histone acetyltransferase complex |
| CC | IDA | GO:0070776 | MOZ/MORF histone acetyltransferase complex |
| BP | NAS | GO:0006334 | nucleosome assembly |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | NAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IDA | GO:0016573 | histone acetylation |
| BP | IBA | GO:0043966 | histone H3 acetylation |
| BP | IDA | GO:0043966 | histone H3 acetylation |
| BP | IBA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IBA | GO:0004402 | histone acetyltransferase activity |
| MF | IDA | GO:0004402 | histone acetyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008134 | transcription factor binding |
| MF | IBA | GO:0010485 | H4 histone acetyltransferase activity |
| MF | IDA | GO:0016407 | acetyltransferase activity |
| MF | IBA | GO:0042393 | histone binding |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: KAT6B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KAT6B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-3214847 | HATs acetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD219 | Bax channel blocker | 5 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD607 | Ubistatin B | 7 |
| iGMDRD148 | Pifithrin-mu | 1 |
| iGMDRD248 | BRD4354 | 6 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD330 | BRD4132 | 4 |
| iGMDRD701 | NVP-AUY922 | 1 |
| iGMDRD560 | MK-2206 | 6 |
| iGMDRD329 | Merck60 | 7 |
| iGMDRD871 | BRD6368 | 4 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD82 | Quiflapon | 5 |
| iGMDRD147 | Prima-1 | 4 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD158 | NSC141540 | 5 |
| iGMDRD213 | SMR000068650 | 7 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD6 | AM-580 | 1 |
| iGMDRD718 | Pyrvinium pamoate | 3 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD380 | Pifithrin-alpha | 7 |
| iGMDRD466 | Chaetocin | 5 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD772 | BRD4770 | 7 |
| iGMDRD420 | Leucascandrolide A | 5 |
| iGMDRD579 | PF750 | 4 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD494 | Neopeltolide | 6 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD888 | Compound 44 | 5 |
| iGMDRD224 | Necrostatin-1 | 4 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD268 | Cerulenin | 6 |
| iGMDRD23 | Gossypol | 5 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD690 | PRIMA-1MET | 7 |
| iGMDRD60 | Quinoclamine | 7 |
| iGMDRD802 | 4-methylfasudil | 8 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD247 | Blebbistatin | 7 |
| iGMDRD441 | TW 37 | 5 |
| iGMDRD318 | PAC-1 | 5 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 4 |
| iGMDRD52 | Rotenone | 5 |
| iGMDRD782 | DC-45-A2 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KAT6B
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