KAT6B


Summary: The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
lysine acetyltransferase 6BMIM:605880Ensembl:ENSG00000156650HGNC:HGNC:17582PA13488071210q22.2

GO terms in KAT6B


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0000123histone acetyltransferase complex
CCNASGO:0000786nucleosome
CCIBAGO:0000790nuclear chromatin
CCIBAGO:0005634nucleus
CCTASGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0032777Piccolo NuA4 histone acetyltransferase complex
CCIBAGO:0070776MOZ/MORF histone acetyltransferase complex
CCIDAGO:0070776MOZ/MORF histone acetyltransferase complex
BPNASGO:0006334nucleosome assembly
BPIEAGO:0006351transcription, DNA-templated
BPNASGO:0006355regulation of transcription, DNA-templated
BPIDAGO:0016573histone acetylation
BPIBAGO:0043966histone H3 acetylation
BPIDAGO:0043966histone H3 acetylation
BPIBAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:1990830cellular response to leukemia inhibitory factor
MFIEAGO:0003677DNA binding
MFIBAGO:0004402histone acetyltransferase activity
MFIDAGO:0004402histone acetyltransferase activity
MFIPIGO:0005515protein binding
MFIDAGO:0008134transcription factor binding
MFIBAGO:0010485H4 histone acetyltransferase activity
MFIDAGO:0016407acetyltransferase activity
MFIBAGO:0042393histone binding
MFIEAGO:0044877protein-containing complex binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: KAT6B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KAT6B


DatabasePathway IDPathway Des.
reactomeR-HSA-3214847HATs acetylate histones
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-4839726Chromatin organization

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD219Bax channel blocker5
iGMDRD154NSC237662
iGMDRD901ELCPK2
iGMDRD512nutlin 33
iGMDRD607Ubistatin B7
iGMDRD148Pifithrin-mu1
iGMDRD248BRD43546
iGMDRD307Manumycin A2
iGMDRD330BRD41324
iGMDRD701NVP-AUY9221
iGMDRD560MK-22066
iGMDRD329Merck607
iGMDRD871BRD63684
iGMDRD286Nsc 6328392
iGMDRD353PD03259011
iGMDRD82Quiflapon5
iGMDRD147Prima-14
iGMDRD137Indisulam2
iGMDRD202Curcumin3
iGMDRD271Brefeldin A3
iGMDRD158NSC1415405
iGMDRD213SMR0000686507
iGMDRD267Oligomycin A2
iGMDRD6AM-5801
iGMDRD718Pyrvinium pamoate3
iGMDRD193Fqi11
iGMDRD61Kinetin riboside4
iGMDRD201SKI II3
iGMDRD71Sparfosic acid3
iGMDRD375GW-4058333
iGMDRD634SCHEMBL26080412
iGMDRD380Pifithrin-alpha7
iGMDRD466Chaetocin5
iGMDRD394BX-7953
iGMDRD599Salermide2
iGMDRD772BRD47707
iGMDRD420Leucascandrolide A5
iGMDRD579PF7504
iGMDRD126Tipifarnib2
iGMDRD494Neopeltolide6
iGMDRD427ABT7372
iGMDRD506Fedratinib3
iGMDRD888Compound 445
iGMDRD224Necrostatin-14
iGMDRD577BIX012946
iGMDRD398Sepantronium2
iGMDRD268Cerulenin6
iGMDRD23Gossypol5
iGMDRD524ISX-93
iGMDRD451Serdemetan3
iGMDRD690PRIMA-1MET7
iGMDRD60Quinoclamine7
iGMDRD8024-methylfasudil8
iGMDRD513BML-2592
iGMDRD247Blebbistatin7
iGMDRD441TW 375
iGMDRD318PAC-15
iGMDRD8012,4-dideoxy-DC-45-A24
iGMDRD52Rotenone5
iGMDRD782DC-45-A22

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KAT6B

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