PPP1R15A
Summary: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:611048 Ensembl IDEnsembl:ENSG00000087074 HGNC IDHGNC:HGNC:14375 PHARMGKB IDPA33632 Map Location19q13.33 | |||||
GO terms in PPP1R15A
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008157 | protein phosphatase 1 binding |
| MF | IPI | GO:0008157 | protein phosphatase 1 binding |
| MF | IBA | GO:0019888 | protein phosphatase regulator activity |
| MF | IC | GO:0019888 | protein phosphatase regulator activity |
| MF | IPI | GO:0019901 | protein kinase binding |
Gene expression in normal tissue: PPP1R15A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPP1R15A
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-2173788 | Downregulation of TGF-beta receptor signaling |
| reactome | R-HSA-2173789 | TGF-beta receptor signaling activates SMADs |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| pid | bmppathway | BMP receptor signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPP1R15A
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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