POLA2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DNA polymerase alpha 2, accessory subunit | Ensembl:ENSG00000014138 | HGNC:HGNC:30073 | PA411 | 11q13.1 |
GO terms in POLA2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003887 | DNA-directed DNA polymerase activity |
| MF | IBA | GO:0046982 | protein heterodimerization activity |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005658 | alpha DNA polymerase:primase complex |
| CC | IDA | GO:0005829 | cytosol |
| BP | IEA | GO:0000060 | protein import into nucleus, translocation |
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | NAS | GO:0006260 | DNA replication |
| BP | IBA | GO:0006270 | DNA replication initiation |
| BP | TAS | GO:0032201 | telomere maintenance via semi-conservative replication |
| BP | IEA | GO:0071897 | DNA biosynthetic process |
Gene expression in normal tissue: POLA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in POLA2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| kegg | hsa03030 | DNA replication - Homo sapiens (human) |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP4022 | Pyrimidine metabolism |
| wikipathways | WP45 | G1 to S cell cycle control |
| wikipathways | WP466 | DNA Replication |
| reactome | R-HSA-113501 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| reactome | R-HSA-113510 | E2F mediated regulation of DNA replication |
| reactome | R-HSA-157579 | Telomere Maintenance |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-174411 | Polymerase switching on the C-strand of the telomere |
| reactome | R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis |
| reactome | R-HSA-174430 | Telomere C-strand synthesis initiation |
| reactome | R-HSA-180786 | Extension of Telomeres |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-68874 | M/G1 Transition |
| reactome | R-HSA-68952 | DNA replication initiation |
| reactome | R-HSA-68962 | Activation of the pre-replicative complex |
| reactome | R-HSA-69002 | DNA Replication Pre-Initiation |
| reactome | R-HSA-69091 | Polymerase switching |
| reactome | R-HSA-69109 | Leading Strand Synthesis |
| reactome | R-HSA-69166 | Removal of the Flap Intermediate |
| reactome | R-HSA-69183 | Processive synthesis on the lagging strand |
| reactome | R-HSA-69186 | Lagging Strand Synthesis |
| reactome | R-HSA-69190 | DNA strand elongation |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69239 | Synthesis of DNA |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-73886 | Chromosome Maintenance |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in POLA2
CLASSFICATION
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