SLC7A11


Summary: This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in SLC7A11


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0003333 amino acid transmembrane transport
BP IEA GO:0006979 response to oxidative stress
BP IEA GO:0007420 brain development
BP IDA GO:0009636 response to toxic substance
BP IEA GO:0015813 L-glutamate transmembrane transport
BP IEA GO:0035094 response to nicotine
Showing 1 to 6 of 17 rows rows per page

Gene expression in normal tissue: SLC7A11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SLC7A11


Loading, please wait...
Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-202733 Cell surface interactions at the vascular wall
reactome R-HSA-210991 Basigin interactions
reactome R-HSA-352230 Amino acid transport across the plasma membrane
reactome R-HSA-382551 Transport of small molecules
reactome R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides
Showing 1 to 6 of 14 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 2
Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC7A11

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​