Summary: This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011].

solute carrier family 7 member 11MIM:607933Ensembl:ENSG00000151012HGNC:HGNC:11059PA359194q28.3

GO terms in SLC7A11

Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0003333amino acid transmembrane transport
BPIEAGO:0006979response to oxidative stress
BPIEAGO:0007420brain development
BPIDAGO:0009636response to toxic substance
BPIEAGO:0015813L-glutamate transmembrane transport
BPIEAGO:0035094response to nicotine
BPTASGO:0050900leukocyte migration
BPIEAGO:0070306lens fiber cell differentiation
BPIEAGO:0070527platelet aggregation
CCIEAGO:0005791rough endoplasmic reticulum
CCTASGO:0005886plasma membrane
CCIDAGO:0009986cell surface
CCTASGO:0016021integral component of membrane
MFIPIGO:0005515protein binding
MFIBAGO:0015179L-amino acid transmembrane transporter activity
MFTASGO:0015327cystine:glutamate antiporter activity

Gene expression in normal tissue: SLC7A11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SLC7A11

DatabasePathway IDPathway Des.
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-210991Basigin interactions
reactomeR-HSA-352230Amino acid transport across the plasma membrane
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-425393Transport of inorganic cations/anions and amino acids/oligopeptides
reactomeR-HSA-425407SLC-mediated transmembrane transport
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
wikipathwaysWP3Transcriptional activation by NRF2
wikipathwaysWP3953mRNA, protein, and metabolite inducation pathway by cyclosporin A
kegghsa04216Ferroptosis - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SLC7A11