Summary: This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss. [provided by RefSeq, Mar 2017].

cell migration inducing hyaluronidase 2MIM:605835Ensembl:ENSG00000135048HGNC:HGNC:11869PA365709q21.13

GO terms in CEMIP2

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004415hyalurononglucosaminidase activity
MFIDAGO:0005509calcium ion binding
MFHDAGO:0045296cadherin binding
BPIDAGO:0030214hyaluronan catabolic process
BPISSGO:1903670regulation of sprouting angiogenesis
CCIDAGO:0005887integral component of plasma membrane
CCTASGO:0016021integral component of membrane
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: CEMIP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CEMIP2

DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CEMIP2