PPIL2
Summary: This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607588 Ensembl IDEnsembl:ENSG00000100023 HGNC IDHGNC:HGNC:9261 PHARMGKB IDPA33588 Map Location22q11.21 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in PPIL2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| MF | IDA | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0016018 | cyclosporin A binding |
| MF | IBA | GO:0034450 | ubiquitin-ubiquitin ligase activity |
| MF | IDA | GO:0034450 | ubiquitin-ubiquitin ligase activity |
Gene expression in normal tissue: PPIL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPIL2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210991 | Basigin interactions |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPIL2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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