MAFF


Summary: The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
MAF bZIP transcription factor FMIM:604877Ensembl:ENSG00000185022HGNC:HGNC:6780PA3053822q13.1

GO terms in MAFF


Term TypeEvidence TypeGO Term IDGO Des.
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFICGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIPIGO:0005515protein binding
MFIDAGO:0043565sequence-specific DNA binding
BPIEAGO:0001701in utero embryonic development
BPTASGO:0006366transcription by RNA polymerase II
BPTASGO:0007567parturition
BPTASGO:0007596blood coagulation
BPIEAGO:0035914skeletal muscle cell differentiation
BPIEAGO:0045604regulation of epidermal cell differentiation
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005739mitochondrion

Gene expression in normal tissue: MAFF

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAFF


DatabasePathway IDPathway Des.
pharmgkbPA165985892Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production
biocartaarenrf2pathwayoxidative stress induced gene expression via nrf2

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAFF

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