Summary: This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015].

alkaline phosphatase, liver/bone/kidneyMIM:171760Ensembl:ENSG00000162551HGNC:HGNC:438PA247291p36.12

Gene Categories:


GO terms in ALPL

Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004035alkaline phosphatase activity
MFIPIGO:0005515protein binding
MFIDAGO:0016462pyrophosphatase activity
MFIEAGO:0046872metal ion binding
BPTASGO:0001501skeletal system development
BPHDAGO:0001649osteoblast differentiation
BPIEAGO:0001958endochondral ossification
BPIEAGO:0003006developmental process involved in reproduction
BPIEAGO:0032496response to lipopolysaccharide
BPIEPGO:0033280response to vitamin D
BPIEAGO:0046677response to antibiotic
BPIEAGO:0051384response to glucocorticoid
BPIEAGO:0071407cellular response to organic cyclic compound
BPIEAGO:0071529cementum mineralization
CCTASGO:0005576extracellular region
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCIEAGO:0031225anchored component of membrane
CCIEAGO:0065010extracellular membrane-bounded organelle
CCHDAGO:0070062extracellular exosome

Gene expression in normal tissue: ALPL

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ALPL

DatabasePathway IDPathway Des.
reactomeR-HSA-163125Post-translational modification: synthesis of GPI-anchored proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
biocartanpp1pathwayregulators of bone mineralization
kegghsa00730Thiamine metabolism - Homo sapiens (human)
kegghsa00790Folate biosynthesis - Homo sapiens (human)
smpdbSMP00017Vitamin B6 Metabolism
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP3413NOTCH1 regulation of human endothelial cell calcification
wikipathwaysWP3971Role of Osx and miRNAs in tooth development
wikipathwaysWP474Endochondral Ossification

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ALPL