FUCA2

Summary: This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namealpha-L-fucosidase 2
OMIM IDMIM:136820
Ensembl IDEnsembl:ENSG00000001036
HGNC IDHGNC:HGNC:4008
PHARMGKB IDPA28424
Map Location6q24.2

Gene Categories:

DRUGGABLE GENOME

GO terms in FUCA2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004560 alpha-L-fucosidase activity
MF IDA GO:0004560 alpha-L-fucosidase activity
MF IPI GO:0005515 protein binding
BP IBA GO:0006004 fucose metabolic process
BP IDA GO:0006004 fucose metabolic process
BP IMP GO:0009617 response to bacterium
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Gene expression in normal tissue: FUCA2

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2

Gene-drug pathway distribution

ERK MAPK signaling1

Pathways in FUCA2


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Database
Pathway ID
Pathway Des.
kegg hsa00511 Other glycan degradation - Homo sapiens (human)
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-597592 Post-translational protein modification
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FUCA2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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