FUCA2
Summary: This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| alpha-L-fucosidase 2 | MIM:136820 | Ensembl:ENSG00000001036 | HGNC:HGNC:4008 | PA28424 | 6q24.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in FUCA2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004560 | alpha-L-fucosidase activity |
| MF | IDA | GO:0004560 | alpha-L-fucosidase activity |
| MF | IPI | GO:0005515 | protein binding |
| BP | IBA | GO:0006004 | fucose metabolic process |
| BP | IDA | GO:0006004 | fucose metabolic process |
| BP | IMP | GO:0009617 | response to bacterium |
| BP | IBA | GO:0016139 | glycoside catabolic process |
| BP | IDA | GO:0016139 | glycoside catabolic process |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IMP | GO:2000535 | regulation of entry of bacterium into host cell |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IBA | GO:0005764 | lysosome |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0035578 | azurophil granule lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: FUCA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FUCA2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00511 | Other glycan degradation - Homo sapiens (human) |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FUCA2
CLASSFICATION
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