RALGAPA1
Summary: This gene encodes a major subunit of the RAL-GTPase activating protein. A similar protein in mouse binds E12, a transcriptional regulator of immunoglobulin genes. The mouse protein also functions in skeletal muscle by binding to the regulatory 14-3-3 proteins upon stimulation with insulin or muscle contraction. A pseudogene of this gene has been identified on chromosome 9. [provided by RefSeq, Oct 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Ral GTPase activating protein catalytic alpha subunit 1 | MIM:608884 | Ensembl:ENSG00000174373 | HGNC:HGNC:17770 | PA165479278 | 14q13.2 |
GO terms in RALGAPA1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005096 | GTPase activator activity |
| MF | ISS | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| BP | IEA | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | ISS | GO:0090630 | activation of GTPase activity |
| CC | ISS | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
Gene expression in normal tissue: RALGAPA1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RALGAPA1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RALGAPA1
CLASSFICATION
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