CNIH2

Summary: The protein encoded by this gene is an auxiliary subunit of the ionotropic glutamate receptor of the AMPA subtype. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system. This protein has been reported to interact with the Type I AMPA receptor regulatory protein isoform gamma-8 to control assembly of hippocampal AMPA receptor complexes, thereby modulating receptor gating and pharmacology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecornichon family AMPA receptor auxiliary protein 2
OMIM IDMIM:611288
Ensembl IDEnsembl:ENSG00000174871
HGNC IDHGNC:HGNC:28744
PHARMGKB IDPA134887358
Map Location11q13.2

Gene Categories:

ION CHANNELTRANSPORTER

GO terms in CNIH2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IEA GO:0000139 Golgi membrane
CC TAS GO:0005789 endoplasmic reticulum membrane
CC TAS GO:0012507 ER to Golgi transport vesicle membrane
CC ISS GO:0014069 postsynaptic density
CC IEA GO:0030054 cell junction
CC ISS GO:0030425 dendrite
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Gene expression in normal tissue: CNIH2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

ERK MAPK signaling1Protein stability and degradation1

Pathways in CNIH2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-199977 ER to Golgi Anterograde Transport
reactome R-HSA-199991 Membrane Trafficking
reactome R-HSA-204005 COPII-mediated vesicle transport
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-446203 Asparagine N-linked glycosylation
reactome R-HSA-5653656 Vesicle-mediated transport
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
iGMDRD353 PD0325901 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CNIH2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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